Protein Details: Neuronal acetylcholine receptor subunit beta-2

Protein ID

ICDB_Pro_0340

Protein Name

Neuronal acetylcholine receptor subunit beta-2

Gene Name

Chrnb2; Acrb2

Organism

Rattus norvegicus (Rat)

Length

500 amino acids

AlphaFoldDB

AF-P12390-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Sequence

MAGHSNSMALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPLFQNYTATTFLHPDHSAPSSK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 83: "Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site"; SITE 118: "Key residue that may play an important stabilizing role for the interaction with alpha-conotoxins PnIA; GID and MII; allowing them to bind deep into the nAChR cleft"; SITE 135: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"; /evidence="ECO:0000305|PubMed:16964981"; SITE 143: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

Expressed in most regions of the CNS

DOI ID

10.1016/0896-6273(88)90208-5; 10.1073/pnas.84.21.7763; 10.1021/bi048918g; 10.1074/jbc.m504229200; 10.1021/bi0611715

RefSeq

NP_062170.1